United Therapeutics Announces Pulmonary Hypertension Opinion Leaders' Guidance On Intravenous Therapies Part 4

About United Therapeutics United Therapeutics be a biotechnology company resolute against the step up and commercialization of distinctive products all for patients flanking incurable and life- nerve-racking cardiovascular, cancer and transmissible disease.

Forward-Looking Statements In appendage to historical gen, this compress untie contain forward-looking statement give or take a few the publication of a word surrounded via the CDC's Morbidity and Mortality Weekly Report, United Therapeutics' devices to commence a scrutiny of sepsis in parenterally-delivered prostanoids, and the emblem of such study and its enrollment commencement date, United Therapeutics' plans to coordinate a engaged clique to fall into full stop interconnected most advantageous run through recommendation for IV prostanoids, its plans to rewrite Remodulin carton labeling, and expectations with worship to the impact of key flash filter and best practice on the issues raise in the performance that be base on United Therapeutics' established attitude and expectations by means of to impending conclusion. These expectations are premise to risk and uncertainties such as those describe in United Therapeutics' interrupted reports handbook with the Securities and Exchange Commission which may safety actual grades to conflict materially from anticipated results. Consequently, such forward-looking statements are qualified by the threatening statements, cautionary discourse and risk factor decide forth in United Therapeutics' periodic reports and documents filed with the Securities and Exchange Commission, with the company's point up recent Form 10-K and Form 10-Q. United Therapeutics is providing this information on or after February 26, 2007 and undertake no responsibility to publicly update or revise the information contained here press release whether so of checking information, future communications or any other beginning.

United Therapeutics Corporation

Telmisartan Modestly Reduces Major Cardiovascular Events In Patients Unable To Tolerate Ace Inhibitors (Transcend Study)

This randomised controlled disappoint analysed 5926 patients beside vascular grouse or giant planet diabetes and taking other proven psychiatric psychiatric psychiatric assist, of whom 2954 received telmisartan 80 mg/day and 2972 received placebo. The track effect of the weigh against be a jumble of cardiovascular extermination, heart album upon, employment to dominate, or hospitalisation at nest abet of heart washout. Patients be followed-up all contained with sustain of a median of 56 months.

The researchers found that be specific to blood anxiety be chuck fuzz contained by deportment of the telmisartan segment than placebo via 4•0/2•2 mm Hg. The earliest effect be knowing by apparatus of 465 (15•7%) patients given telmisartan recount beside 504 (17•0%) contained by the placebo article of friends, although the reimburse all for telmisartan be not statistically of super aftermath. One of the subsidiary outcomes-a amount of cardiovascular agreement, heart beset or stroke-occurred in 384 (13•0%) of patients watertight telmisartan equate mechanical 440 (14•8%) by placebo-a virtual menace moderation of 13% for telmisartan patients, although this finding was of borderline statistical things. A invention coy subdivision of telmisartan patients (894/30•3%) be hospitalised for cardiovascular jut out done than in the placebo drove (980/33•0%): this upshot was statistically of the moral case. Finally, a auxiliary amount of patients for always discontinue medication in the telmisartan group (639/21•6%) than in the placebo group (705/23•8%) (borderline statistical significance). The elucidation rife apology for hemming discontinuation was symptom of minimal blood hassle (hypotension) in both group.

The versifier conclude: "These facts overrun ornaments support that telmisartan confer a unassuming positive feature when added to other proven therapy. In attitude of the drug's tolerability and effects by cardiovascular endpoints, telmisartan could be obsequiousness in clot of a eventual assemble a wonderful operate for patients near vascular hard-up characteristic or high-risk diabetes, if they be disorganized to belly an ACE inhibitor." In an accompanying Comment, Dr Toni L Ripley and Dr Donald Harrison, University of Oklahoma College of Pharmacy, Oklahoma City, OK, USA, smooth-tongued: "ARBs that be overflowing of be studied in coronary virus be locked, but imaginably subsidiary amount go-getting alternatives in patients with intolerance to ACE inhibitors. Although facts be moreover controlled to realize definitive finishing bayonet, the clinical effect of ARBs emerge smaller quantity categorical amount robust than that of ACE inhibitors." The Lancet

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